The very evidence that all living organisms are alive is that they can produce a response to external and internal stimuli. These stimuli makes discomfort and when it gets intensified to the degree where it disturbs daily life, we call them 'pain. ' In terms of the duration of pain, the pain is sorted into acute and chronic pain, and although these two look similar, they assume very different aspects. Generally, the duration of pains within three months is classified as acute pains and those

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... ve three months would be chronic pains. Once again, chronic pains are divided into chronic malignant pain and chronic non-malignant pain. Usually, the chronic pains accompany various symptoms such as decreased appetite, indigestion, failure to thrive, autonomic dysreflexia, depression, insomnia, constipation, etc., so it is often called chronic pain syndrome (CPS). Most acute pains are easy to find their cause of pain, and the majority of them are known to be controlled when treated with remedy of cause along with enough rest, adequate analgesics and anti-inflammatory drugs. However, different from acute pains, the chronic pains can linger after being treated with remedy of cause and they are known to react better with antianxiety or an-tidepressant drugs. While treating these pains, that seem to not be easily solved to the bottom, in case of the US of 2008, the death toll by drug abuse unfortunately surpassed that of traffic accidents (Fig. 1 ) 4) . According to Gislason 9) , the risk of death is said to be continuing on patients with myocardial infarction who are treated with common NSAIDs, after they are traced from one-week to fiveyear term. This risk of death particularly arose when they were prescribed with COX-2 inhibitors in order to reduce complications such as gastritis or gastric ulcer. Among these inhibitors, diclofenac is even more perilous, so it was recommended by Health Canada to limit the dosage of medicines containing diclofenac from 150 mg to 100 mg [8] [9] [10] . Many diverse influences are responsible for the current state of the public health (Fig. 2 ) 20, 22, 30) . However, it is not enough to demonstrate that the majority of today's chronic diseases could be prevented or ameliorated by changes in lifestyle 5) . We must also ask what contributes to such unhealthy lifestyles. It is critical that we understand how great a proportion of environment and lifestyle is influenced by conditions beyond the control of 16