Tuneable access to indole, indolone and cinnoline derivatives from a common 1,4-diketone Michael acceptor [post]

Dalel El-Marrouki, Sabrina Touchet, Abderrahmen Abdelli, Hédi M'Rabet, Mohamed Lotfi Efrit, Philippe C Gros
2020 unpublished
A convergent strategy is reported for the construction of nitrogen-containing heterocycles from common substrates: 1,4-diketones and primary amines. Indeed, by just varying substrates, substituents or heating mode it is possible to selectively synthesize indole, indolone (1,5,6,7-tetradihydroindol-4-one) or cinnoline (5,6,7,8-tetrahydrocinnoline) derivatives in moderate to excellent yields.
doi:10.3762/bxiv.2020.56.v1 fatcat:b6kz4bgzzrdl7hxzoitmv6cu4i