Global epidemiology and related prognosis of traumatic arterial injuries associated with fractures of the lower limb: protocol for a systematic review and meta-analysis
Review question / Objective: 1. What is the prevalence of TAI associated with FF and / or TF in trauma to the lower limb? 2. What is the most common pathological form of AI associated with FF and / or TF? 3. What is the amputation rate and mortality after revascularization of an AI to FF and / or TF? Condition being studied: Arterial injury is a big concern after lower limb fracture. Those injuries are common, and potentially devastating problem that carries the greater risk of limb loss,
... of limb loss, functional disability and mortality. The independent predictors of amputation include complex soft tissue injury, nerve injury, and extremity abbreviated injury score (MULLENIX et al., 2006). The overall mortality varies from 2.8% to 9% (KAUVAR et al., 2011; ASENSIO et al., 2006), with predictors including age >45 years, Injury Severity Score >25, associated venous and abdominal injury, hypotension, hypothermia, and acidosis; coagulopathy in the operating room and the need for polytetrafluoroethylene (PTFE) repair (ASENSIO et al., 2006). Time taken for treatment, generally estimated at less than 6 hours, constitutes a factor of good functional prognosis for the member. This is explained by the fact that muscle pain occurs after 6 hours of anoxia. INPLASY registration number: This protocol was registered with the International Platform of Registered Systematic Review and Meta-Analysis Protocols (INPLASY) on 17 July 2020 and was last u p d a t e d o n 1 7 J u l y 2 0 2 0 ( r e g i s t r a t i o n n u m b e r INPLASY202070078).