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OptDesign: Identifying Optimum Design Strategies in Strain Engineering for Biochemical Production
[article]
2021
bioRxiv
pre-print
Computational tools have been widely adopted for strain optimisation in metabolic engineering, contributing to numerous success stories of producing industrially relevant biochemicals. However, most of these tools focus on single metabolic intervention strategies (either gene/reaction knockout or amplification alone) and rely on hypothetical optimality principles (e.g., maximisation of growth) and precise gene expression (e.g., fold changes) for phenotype prediction. This paper introduces
doi:10.1101/2021.12.10.472123
fatcat:jbyzuw7atrfm7li4pjjp2vrelm