Longitudinal genome-wide DNA methylation analysis uncovers persistent early-life DNA methylation changes

Raúl F. Pérez, Pablo Santamarina, Juan Ramón Tejedor, Rocío G. Urdinguio, Julio Álvarez-Pitti, Pau Redon, Agustín F. Fernández, Mario F. Fraga, Empar Lurbe
2019 Journal of Translational Medicine  
Early life is a period of drastic epigenetic remodeling in which the epigenome is especially sensitive to extrinsic and intrinsic influence. However, the epigenome-wide dynamics of the DNA methylation changes that occur during this period have not been sufficiently characterized in longitudinal studies.
doi:10.1186/s12967-018-1751-9 pmid:30626398 pmcid:PMC6327427 fatcat:m7bejtslfrg45mcszxqcepdty4