Ontogenetic and Phylogenetic Approaches for Studying the Mechanisms of Cognitive Dysfunctions [chapter]

Igor А. Zhuravin, Nadezhda M. Dubrovskaya, Natalia L. Tumanova, Dmitrii S. Vasilev, Natalia N. Nalivaeva
2018 Evolutionary Physiology and Biochemistry - Advances and Perspectives  
This chapter summarizes the phylogenetic and ontogenetic approaches for studying cognitive disorders such as Alzheimer's disease. It gives an extended example of evaluation of animal behavior and brain properties using an original model of prenatal hypoxia in rats by various physiological, behavioral, immunohistochemical, molecular biological, and biochemical techniques at different stages of postnatal development, which provide a better understanding of the pathological processes in the human brain during the development of neurodegeneration.
doi:10.5772/intechopen.73666 fatcat:xvygciqdpndjvgpffxnsqlsgyi