Carcinogen Exposure among Canadian Tobacco Users: Changes in NNK Exposure from 2007–2009 through 2012–2013

Christine D. Czoli, David Hammond
2018 Cancer Epidemiology, Biomarkers and Prevention  
Tobacco-specific nitrosamines (TSNAs) are a class of carcinogens found in tobacco products, whose levels can vary considerably depending on tobacco blends and manufacturing processes. The current study examined whether recent increases in levels of the TSNA NNK [4-(methylnitrosamino-1-(3-pyridyl)-1-butanone] in Canadian cigarettes translated into differences in exposure among Canadian tobacco users. Methods: Nationally representative data from the Canadian Health Measures Survey (CHMS) were
more » ... to measure levels of total urinary NNAL [4-(methylnitrosamino)-1-(3pyridyl)-1-butanol], a metabolite of the TSNA NNK, among tobacco users. Data from CHMS Cycle 3 (2012-13) were used to examine NNAL, and linear regression was used to examine predictors. Data from CHMS Cycle 1 (2007-09) and Cycle 3 (2012-13) were used to examine changes in NNAL over time. Results: From
doi:10.1158/1055-9965.epi-17-0715 pmid:29358222 fatcat:awyogezx7fejfbvl56iqydmnpe