This is a review from 2 studies that determine the concentration of seminal fructose and show the correlations between seminal fructose concentration with sperm concentration, vitality and motility (progressive). Besides, these studies also show the reason of man infertility cases which azoospermia and no seminal fructose. Materials and methods: Include random 60 normozoospermia, 60 oligozoospermia semen. Determine fructose concentration by ROE method. 25 azoospermia cases with no fructose had

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... een examined and proceed percutaneous epididymis sperm aspiration (PESA) to find the infertility reason. Results: Fructose concentration of normozoospermia: 1,601 ± 0,604 (g/l) significant lower than oligozoospermia: 1,881 ± 0,640 (g/l). Fructose seminal concentration has negative correlations with sperm concentration (R = -0.156; p > 0.05); sperm vitality (R = -0.065; p > 0.05); sperm progressive motility (R = -0.186; p < 0.05). Examine and process percutaneous epididymis sperm aspiration (PESA), 25 azoospermia with no fructose cases have diagnosed congenital bilateral absence of the vas deferens (CBAVD). Conclusions: Seminal fructose concentration of normozoospermia group is significant lower than oligozoospermia group. Fructose seminal concentration has negative correlations with sperm concentration, concentration and motility. 100% azoospermia cases with no seminal fructose have diagnosed CBAVD.