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Neoplastic Non-Angiogenic Growth by Means of Vascular Co-Option
Journal of Clinical & Experimental Pathology
The creation of the term angiogenesis goes back to 1787  and the role of vessels in cancer has being studied since. In 1971 Folkman  introduced the hypothesis, until now widely accepted, that tumour growth is angiogenesis dependent  . However, the discovery that cancer can also grow without angiogenesis, by co-opting pre-existing vessels both in humans [4-7] and in mice  has demonstrated that this is not always the case. The observation that cancer cells can exploit pre-existingdoi:10.4172/2161-0681.1000232 fatcat:sx67ubltifg7vantp4iclfhwvi