Objecti ves: To study the magnitude of lesions in gallbladder and to study different types of histopathological lesions occurring in the gallbladder and to co-relate them clinicopathologically. Design and Methods: Cholecystectomy specimens received in Pathology department of our hospital for histopathological examination were included in this study. Patients age, sex, p resenting symptoms, serum bilirubin levels and USG findings among others were noted. After gross examination min imu m three

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... ctions one each from neck, fundus and body were given. The sections were subjected to routine paraffin processing and H&E staining.Special stains like PAS, Mucicarmine were perfo rmed whenever indicated. The sections were studied microscopically, and findings noted. Results: Variety of lesions can be found if cholecystectomy specimens were examined met iculously.Patients usually present with signs and symptoms of long duration and with vague complaints like pain in abdo men, nausea, dyspepsia. Most of the cases seen were of chronic calculus cholecystitis. These cases were predominant in females and associated mostly with pig mented stones. All cases of carcinoma gallbladder were missed on clinical examination and ultrasonography. Conclusion: Diagnosis was established on histopathology. Hence histopathology remains gold standard for revealing unsuspected lesions