A novel scheme for fully scalable White Monte Carlo ͑WMC͒ has been developed and is used as a forward solver in the evaluation of experimental time-resolved spectroscopy. Previously reported scaling problems are avoided by storing detection events individually, turning spatial and temporal binning into post-simulation activities. The approach is suitable for modeling of both interstitial and noninvasive settings ͑i.e., infinite and semi-infinite geometries͒. Motivated by an interest in in vivo

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... ptical properties of human prostate tissue, we utilize WMC to explore the low albedo regime of timedomain photon migration-a regime where the diffusion approximation of radiative transport theory breaks down, leading to the risk of overestimating both reduced scattering ͑ s Ј͒ and absorption ͑ a ͒. Experimental work supports our findings and establishes the advantages of Monte Carlo-based evaluation.