Anti-cyclic citrullinated peptide antibodies – a role in rheumatoid arthritis and the possibility of seroconversion: A focus on abatacept

N. V. Chichasova
2017 Sovremennaâ Revmatologiâ  
The detection of anti-cyclic citrullinated peptide (anti-CCP) antibodies plays a diagnostic and statistical predictive role in rheumatoid arthritis (RA). The decreased concentration of anti-CCP antibodies or their seroconversion is observed for not all groups of anti-inflammatory drugs. Seropositivity for anti-CCP antibodies is a predictor of the higher efficacy of abatacept (ABC). The possibility of seroconversion of anti-CCP antibodies, like rheumatoid factor, during treatment with ABC is
more » ... ent with ABC is associated with the more pronounced suppression of clinical symptoms of RA activity and progressive joint destruction, with remission achievement in a large proportion of patients.
doi:10.14412/1996-7012-2017-1-79-86 doaj:01a76c0801134a158581734baa044f42 fatcat:rykdj3sjafezvicr4std7mx4hy