Study on the ability of the three-dose-volume-histogram-gamma (3DVH-γ) analysis and bio-mathematical model in detecting dose changes caused by dose-calculation-grid-size (DCGS) [post]

Han Bai, Sijin Zhu, Xingrao Wu, Xuhong Liu, Feihu Chen, Jiawen Yan
2020 unpublished
Objective : To explore the efficacy and sensitivity of 3DVH-γanalysis and bio-mathematical model for cervical cancer in detecting dose changes caused by dose-calculation-grid-size(DCGS). Methods: 17 patients' plans for cervical cancer were enrolled(Pinnacle TPS,VMAT), and the DCGS was changed from 2.0mm to 5.0mm to calculate the planned dose respectively. The dose distribution calculated by DCGS = 2.0mm as the " reference " data set (RDS) , the dose distribution calculated by the rest DCGS as
more » ... the rest DCGS as the"measurement"data set (MDS), the 3DVH-γ passing rates and the (N)TCPs of the all structures under different DCGS were obtained , and then analyze the ability of 3DVH-γ analysis and (N)TCP model in detecting dose changes and what factors affect this ability. Results: The effect of DCGS on planned dose was obvious. When the γ-standard was 1.0mm, 1.0% and 10.0%, the difference of the results of the DCGS on dose-effect could be detected by 3DVH-γ analysis ( p s<0.05). With the decline of the standard, 3DVH-γ analysis' ability to detect this difference shows weaker. When the standard was 1.0mm, 3.0% and 10.0%, the p value of >0.05 accounted for the majority. With DCGS=2.0mm being RDS, ∆γ-passing-rate presented the same trend with ∆(N)TCPs of all structures except for the femurs only when the 1.0mm, 1.0% and 10.0% standards were adopted for the 3DVH-γ analysis. Conclusions: The 3DVH-γ analysis and bio-mathematical model can be used to analyze the effect of DCGS on the planned dose. For comparison, the former's detection ability has a lot to do with the designed standard, and the latter's capability is related to the parameters and calculated accuracy instrinsically.
doi:10.21203/rs.3.rs-17543/v2 fatcat:j5rh4gf23resncogjp6jkeqyly