Internet Archive Scholar

SARS-CoV-2-induced impaired immune response by Prostaglandin E2 is accelerated by age, male sex and air pollution [post]

Melanie Ricke-Hoch, Elisabeth Stelling, Lisa Lasswitz, Antonia-Patricia Gunesch, Martina Kasten, Francisco J. Zapatero-Belinchón, Graham Brogden, Gisa Gerold, Karin Battmer, Thomas Pietschmann, Virginie Montiel, Jean-Luc Balligand (+18 others)
2020 unpublished

Preserved Fulltext

fulltext thumbnail
Web Archive Capture PDF (1.2 MB)
https://web.archive.org/web/20210103065320/https://assets.researchsquare.com/files/rs-129664/v1/41975b21-dc50-4596-b858-8ed01e6eefb8.pdf

A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2021; you can also visit the original URL. The file type is application/pdf.

The SARS-CoV-2 coronavirus has led to a pandemic with millions of people affected. The present study finds prostaglandin E2 (PGE2) blood levels elevated in COVID-19 patients with positive correlation with disease severity. SARS-CoV-2 induces PGE2 generation and secretion in infected lung epithelial cells by upregulating cyclo-oxygenase (COX)-2 and reducing the PG-degrading enzyme 15-hydroxyprostaglandin-dehydrogenase. Also living human-lung-precision-slices infected with SARS-CoV-2 display
more » ... ulated COX-2. PGE2 in serum of COVID-19 patients lowers the expression of Paired-Box-Protein-Pax-5 (PAX5), a master regulator of B-cell survival, proliferation and differentiation, in both human and mouse pre-B-cells, while the PGE2 inhibitor taxifolin directly reduces SARS-CoV-2-induced PGE2 production and attenuates viral replication. Risk-factors for severe disease courses, i.e. older age, male sex and air pollution are associated with higher PGE2 production and lower PAX5 expression in pre-B-cells. Since PGE2 acts broadly immunosuppressive its elevation might reduce the early anti-viral defense and its inhibition may therefore reduce severe disease courses.
doi:10.21203/rs.3.rs-129664/v1 fatcat:2bbgih6ravc5xcjhzlat4eauom
Open Access
Citation

Melanie Ricke-Hoch, Elisabeth Stelling, Lisa Lasswitz, Antonia-Patricia Gunesch, Martina Kasten, Francisco J. Zapatero-Belinchón, Graham Brogden, Gisa Gerold, Karin Battmer, Thomas Pietschmann, Virginie Montiel, Jean-Luc Balligand, Federica Facciotti, Emilio Hirsch, Husni Elbahesh, Guus Rimmelzwaan, Anne Hoefer, Mark Kühnel, Danny Jonigk, Julian Eigendorf, Uwe Tegtbur, Lena Mink, Michaela Scherr, Thomas Illig, Axel Schambach, Tobias Pfeffer, Birgit Andrée, Andres Hilfiker, Axel Haverich, Denise Hilfiker-Kleiner. "SARS-CoV-2-induced impaired immune response by Prostaglandin E2 is accelerated by age, male sex and air pollution." (2020)