We compared the efficacy of granisetron plus dexamethasone with that of granisetron alone for preventing nausea and vomiting in parturients undergoing cesarean section under spinal anesthesia. In a randomized, double-blinded manner, 120 patients received either granisetron 3 mg (Group I, n ϭ 60) or granisetron 3 mg plus dexamethasone 8 mg (Group II, n ϭ 60) IV immediately after clamping of the fetal umbilical cord. A complete response, defined as no emetic symptoms and no need for another

more »

... antiemetic medication in the intraoperative, postdelivery period was 83% in Group I and 98% in Group II (P ϭ 0.008); the corresponding rates during the first 24 h after surgery was