blood-pressure [Editorial]. Lancet 1982;ii: 965-7. 2 Orlov SN, Postnov YV. Ca2binding and membrane fluidity in essential and renal hypertension. Clin Sci 1982;63:218-24. 3 Jones AW. Altered ion transport in large and small arteries from spontaneously hypertensive rats and the influence of calcium. Circ Res 1974;34, suppl 1:1 17-22. 4 Heagerty AM, Milner M, Bing RF, Thurston H, Swales JD. Leucocyte membrane sodium transport in normotensive populations: dissociation of abnormalities of sodium

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... ux from raised blood pressure. Lancet 1982 ;ii :894-6. 5Blaustein MP. Sodium ions, calcium ions, blood pressure regulation and hypertension: a reassessment and a hypothesis. Am J Physiol 1977; 232 :C165-73. 6 Anonymous. Calcium antagonists in hypertension [Editorial]. Lancet 1982;ii :307-8. 7 Edmondson RPS, Thomas RD, Hilton PJ, Patrick J, Jones NF. Abnormal leucocyte composition and sodium transport in essential hypertension. Lancet 1975 ;i: 1003-5. 8 Braunwald E. Mechanism of action of calcium-channel-blocking agents. N EnglJ Med 1982 ;307:1618-27. 9 Motulsky HJ, Snavely MD, Hughes RJ, Insel PA. Interaction of verapamil and the other calcium channel blockers with a, and a2 adrenergic receptors. Circ Res 1983;52:226-31. 10 Robinson BF, Dobbs RJ, Bayley S. Response of forearm resistance vessels to verapamil and sodium nitroprusside in normotensive and hypertensive men: evidence for a functional abnormality of vascular smooth muscle in primary hypertension. Abstract Gastric mucosa was studied histologically in 141 patients. Eighty two had undergone vagotomy and gastrojejunostomy between 15 and 25 years previously for duodenal ulcer, and 59 control patients had a long history (minimum 15 years) of duodenal ulcer treated medically. No carcinoma was found in either group. Two patients with severe dysplasia and 13 patients with moderate dysplasia were found in the study group, compared with none in the control group (p <0 01). Intestinal metaplasia was seen in 44 (53%) of the study group and 16 (27%) of the control group (p <0 01). Atrophy and gastritis were more severe (p <0 01 for atrophy; p=0 05 for gastritis) in the study group. Gastric mucosal changes were more severe after surgical treatment for duodenal ulcer than after medical treatment, and possibly a high incidence of gastric carcinoma may occur 25 years after vagotomy and gastrojejunostomy. Abstract Gastric biopsy specimens were taken in 33 patients before and after procedures to divert bile (construction of Roux loop in 19, closure of gastrojejunostomy in 14). Each biopsy specimen was assessed for dysplasia, intestinal metaplasia, atrophy, and gastritis, each variable being given a score ranging from 0 to 6. Patients were given