Nanodroplets on chemically structured substrates move under the action of disjoining pressure induced forces. A detailed analysis of them shows that even in the absence of long-ranged lateral variations of the effective interface potential, already the fact, that due their small size nano-droplets do not sample the disjoining pressure at all distances from the substrate, can lead to droplet motion towards the less wettable part of the substrate, i.e., in the direction opposite to the one

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... d on the basis of macroscopic wettability considerations.