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Xrn1 is a deNADding Enzyme Modulating Mitochondrial NAD Levels
[article]
2021
bioRxiv
pre-print
The existence of non-canonical nicotinamide adenine diphosphate (NAD) 5′-end capped RNAs is now well established. Nevertheless, the biological function of this nucleotide metabolite cap remains elusive. Here, we show that the yeast Saccharomyces cerevisiae cytoplasmic 5′-end exoribonuclease Xrn1 is also a NAD cap decapping (deNADding) enzyme that releases intact NAD and subsequently degrades the RNA. The significance of Xrn1 deNADding is evident in a deNADding deficient Xrn1 mutant that still
doi:10.1101/2021.06.25.449970
fatcat:pvh6wrrudnftljz6nyqiuuuaga