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A multi-omic analysis of optineurin proteinopathy in a yeast model suggests the involvement of lipid metabolism in Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis (ALS) is an incurable fatal neurodegenerative disease for which the precise mechanisms of toxicity remain unclear despite some significant advances in our understanding of the underlying genetic basis. A holistic, integrated view of cellular changes will be critical to understanding the processes of neurodegeneration and the development of effective treatments. Mutant forms of optineurin (a ubiquitin-binding protein involved in autophagy, membrane trafficking, anddoi:10.1101/605998 fatcat:aca54zaks5dylm4ek4neo2yngi