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Analytical and clinical performances of a SARS-CoV-2 S-RBD IgG assay: comparison with neutralization titers
Clinical Chemistry and Laboratory Medicine
SARS-CoV-2 serology presents an important role in several aspects of COVID-19 pandemic. Immunoassays performances have to be accurately evaluated and correlated with neutralizing antibodies. We investigated the analytical and clinical performances of a SARS-CoV-2 RBD IgG assay, automated on a high throughput platform, and the correlation of the antibodies (Ab) levels with the plaque reduction neutralization (PRNT50) Ab titers. A series of 546 samples were evaluated by SARS-CoV-2 RBD IgG assaydoi:10.1515/cclm-2021-0313 pmid:33855843 fatcat:nimwvhlqlfcrpbs4np27rnj434