Observation on the effect of carbetocin in preventing postpartum hemorrhage caused by uterine inertia

Hong-Li Zhang, Rui Bai
2017 Journal of Hainan Medical University  
Objective: To explore the effect of carbetocin in preventing postpartum hemorrhage caused by uterine inertia. Methods: A total of 256 puerpera with single full-term delivery who were admitted in our hospital from May, 2015 to May, 2016 were included in the study and divided into the vaginal delivery group and cesarean section group with 128 cases in each group according to the delivery ways. According to the medication, each group was divided into the carbetocin group and oxytocin group with 64
more » ... tocin group with 64 cases in each group. After fetus delivery, the puerpera in the carbetocin group were given intravenous injection of carbetocin (100 μg), while the puerpera in the oxytocin group were given intravenous injection of oxytocin (10 U)+0.9% NaCl (500 mL) for 2 h. The amount of bleeding at delivery, 2 h and 24 h after delivery in each group was observed. A volume of 5 mL elbow venous blood before delivery and 24 h after delivery was extracted. The automatic blood cell analyzer was used to detect the decreased value of 24 h hemoglobin in each group. The coagulation detector was used to detect PT, APTT, and FIB before delivery and 24 h after delivery. The blood pressure and heart rate before and after medication in each group were observed. Results: The amount of bleeding at delivery, 2 h and 24 h after delivery in the carbetocin group was significantly less than that in the oxytocin group (P<0.05). The decreased value of 24 h hemoglobin after delivery in the carbetocin group was significantly less than that in the oxytocin group (P<0.05). The indicators of coagulation function 24 h after delivery in each group were not significantly changed (P>0.05). The heart rate and blood pressure after medication in each group were not significantly changed when compared with before medication (P>0.05). Conclusions: Carbetocin can effectively prevent the postpartum hemorrhage caused by uterine inertia, and is safe and effective in application of vaginal delivery and cesarean section; therefore, it deserves to be widely recommended in the clini [...]
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