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Association of endothelin-1 and cell surface adhesion molecules levels in patients with systemic sclerosis
AbstractObjectivesEndothelin-1 (ET-1) has been implicated in the pathogenesis of inflammatory and fibrotic diseases, including systemic sclerosis. In addition to modulating vascular tone and extracellular matrix turnover, ET-1 up-regulates cell surface adhesion molecules–intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1).The aim of the study was to evaluate the diagnostic value of the detection of ET-1, VCAM-1 and ICAM-1 in the diagnosis of systemicdoi:10.1515/labmed-2020-0050 fatcat:shahegi3cfd7hjvh72seszv3k4