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Int J Clin Exp Pathol
Sex determining region Y-box protein 5 (SOX5) is involved in the regulation of embryonic development and associated with various types of cancers. However, the expression and biological function of SOX5 in osteosarcoma remains to be investigated. Here, we found that SOX5 mRNA was significantly elevated in osteosarcoma tissues compared with bone cyst tissues. In vitro experiments demonstrated that knockdown of SOX5 by RNA interference in two osteosarcoma cell lines, MG63 and U2OS cells,fatcat:uahwvzqlrfgdrbci7rpkweex5q