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AbstractAntimicrobial agents are among the most frequently prescribed medications in long-term–care facilities (LTCFs). Therefore, it is not surprising thatClostridium difficilecolonization andC. difficile-associated diarrhea (CDAD) occur commonly in elderly LTCF residents.C. difficilehas been identified as the most common cause of non-epidemic acute diarrheal illness in nursing homes, and outbreaks of CDAD in LTCFs have also been recognized. This position paper reviews the epidemiology anddoi:10.1086/501997 pmid:12452300 fatcat:kxfqtljpgfat7b5uhuzhpfbftm