Current Methods for Recombination Detection in Bacteria

Anton E. Shikov, Yury V. Malovichko, Anton A. Nizhnikov, Kirill S. Antonets
2022 International Journal of Molecular Sciences  
The role of genetic exchanges, i.e., homologous recombination (HR) and horizontal gene transfer (HGT), in bacteria cannot be overestimated for it is a pivotal mechanism leading to their evolution and adaptation, thus, tracking the signs of recombination and HGT events is importance both for fundamental and applied science. To date, dozens of bioinformatics tools for revealing recombination signals are available, however, their pros and cons as well as the spectra of solvable tasks have not yet
more » ... een systematically reviewed. Moreover, there are two major groups of software. One aims to infer evidence of HR, while the other only deals with horizontal gene transfer (HGT). However, despite seemingly different goals, all the methods use similar algorithmic approaches, and the processes are interconnected in terms of genomic evolution influencing each other. In this review, we propose a classification of novel instruments for both HR and HGT detection based on the genomic consequences of recombination. In this context, we summarize available methodologies paying particular attention to the type of traceable events for which a certain program has been designed.
doi:10.3390/ijms23116257 pmid:35682936 pmcid:PMC9181119 fatcat:qrp4jjmrxbavtdctlqhxoyqi74