The Transcranial LED Therapy (TCLT) is a modality of low-level energy therapy based on the principle of photons delivered in a non-invasive manner for the rehabilitation of some neurological conditions such as psychological disorders, traumatic brain injuries, and neurodegenerative diseases among others. Because the phototherapy approach has attracted interest in the scientific medical field we discuss the action of TCLT at the cellular level in this review. Cytochrome c oxidase is the main

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... et of TCLT for therapeutic effects by enhancing cerebral blood flow. This enzyme boosts cell respiration and energy production, which induces cell proliferation and reduces apoptosis in Alzheimer and Parkinson's diseases. Thus, TCLT is a safe, non-invasive, and low cost alternative treatment compared to other treatment modalities for clinical neurological disorders.