Improvement of physical capacity in patients undergoing transcatheter closure of atrial septal defects

Paweł Prochownik, Tadeusz Przewłocki, Piotr Podolec, Piotr Wilkołek, Bartosz Sobień, Urszula Gancarczyk, Natalia Podolec, Monika Komar
2018 Advances in Interventional Cardiology  
A b s t r a c t Introduction: Atrial septal defect (ASD) is the most common congenital cardiac anomaly diagnosed in adults. It often remains asymptomatic until the fourth or fifth decade of life. Significant left-to-right interatrial shunting is associated with the risk of heart failure, pulmonary hypertension and atrial fibrillation. Percutaneous ASD closure is a recognized method of treatment. Aim: To evaluate the clinical outcomes and physical capacity in patients undergoing transcatheter
more » ... sure of ostium secundum ASD. Material and methods: One hundred and twenty adult patients (75 females and 45 males) with a mean age of 43.1 ±13.3 (17-78) years who underwent transcatheter device closure of ostium secundum ASD were analyzed. Clinical evaluation and transthoracic color Doppler echocardiographic study were repeated in all patients before as well as 1 and 24 months after the procedure. To assess the physical capacity symptom-limited treadmill exercise tests with respiratory gas-exchange analysis were performed in all patients before the procedure and after 24 months of follow-up. Results: The devices were successfully implanted in all patients. During 24 months of follow-up all patients showed significant clinical and spiroergometric improvement of exercise capacity, and a significant decrease of right heart chamber overload features on echocardiography. Conclusions: Transcatheter closure of ASD in patients with significant shunt resulted in significant clinical and hemodynamic improvement regardless of the baseline functional class.
doi:10.5114/aic.2018.74360 pmid:29743909 pmcid:PMC5939550 fatcat:cqnrshiw5nhy7pgqvkj7g66p7i