The creation of natural definitions is a phase of any methodology to build formal ontologies. In order to reach formal definitions, one should first create natural language definitions according to sound principles. We gather a set of principles available in literature and organize them in a list of stages that one can use to create good definitions in natural language. In order to test the set of principles, we conducted a case study in which we create definitions in the domain of cancer, more

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... specifically, definitions for acute myeloid leukemia. After creating and validating the definition of this specific kind of leukemia, we offer remarks about the experiment.