SARS-CoV-2 mutations among minks show reduced lethality and infectivity to humans [article]

Tomokazu Konishi
2020 bioRxiv   pre-print
SARS-CoV-2 infection in minks has become a serious problem, as the virus may mutate and reinfect humans; some countries have decided to cull minks. Here, the virus sequencing data in minks were analysed and compared to those of human-virus. Although the mink-virus maintained the characteristics of human-virus, some variants rapidly mutated, adapting to minks. Some mink-derived variants infected humans, which accounted for 40% of the total SARS-CoV-2 cases in the Netherlands. These variants
more » ... These variants appear to be less lethal and infective compared to those in humans. Variants that have mutated further among minks were not found in humans. Such mink-virus might be suitable for vaccination for humans, such as in the case of the smallpox virus, which is less infective and toxic to humans.
doi:10.1101/2020.12.23.424267 fatcat:homem355pvhanad7fy5xzh5dda