Objective (s): Nausea and vomiting of pregnancy is a list of the most common pregnancy problem. The combination of non-drug treatments involves nutrition, lifestyle changes, and alternative medicine to treat nausea and vomiting of pregnancy is paid less attention as a published guidelines. The aim of this research was to determine the effect of an educational intervention based on Ottawa Guideline in nausea and vomiting at first trimester of pregnancy. Methods: This single-blind clinical trial

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... as conducted on 60 pregnant women with nausea and vomiting complication from a selected primary healthcare centers in Mashahd (Iran). The participants were randomly assigned to two groups, an experimental group and a control group. The experimental group received the Ottawa training guide (two sessions: general, attention, nutrition, lifestyle, alternative medicine, and acupressure) during two 60-minute sessions and the control group received the usual care. Depression Anxiety and Stress Scale (DOS-21(, the Rhodes index of nausea and vomiting, and Czech playlists training manual Ottawa were used. The Chi-square tests, Fisher Mann-Whitney U, independent and paired t-test were used for analysis. Results: There was a statistically significant difference between the two groups in terms of nausea (p= 0.002), vomiting (P = 0.007), and retching (P = 0.009) on the fourth weeks after the initial intervention. (p =<0.001). The mean of total score of nausea, vomiting and gagging in the second and fourth weeks in the experimental group were significantly lower than the control group (p <0.001). Conclusion: The Czech playlists training manual Ottawa can be effective in reducing nausea, vomiting in pregnant women.