We present a case of gestational hypertension, eclampsia, and postpartum depression in a 39-year-old nulliparous pregnant patient following multiple prenatal severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) infections. After an initial mild first trimester case of coronavirus disease-19 (COVID-19), the patient received a 2-dose mRNA vaccine against SARS-CoV-2. Despite vaccination, she again contracted COVID-19 during her third trimester of pregnancy. She subsequently

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... d gestational hypertension which necessitated a cesarean section at 38 + 4 weeks. The patient delivered a healthy neonate, however her postpartum course was complicated by eclampsia and postpartum depression. While research suggests COVID-19 in pregnancy is associated with poor maternal and fetal outcomes, the exact mechanisms remain unclear and approach to management of affected patients presents a distinct challenge to clinicians. This case bolsters current literature and emphasizes the necessity of continued research into the effects of COVID-19 in pregnant and postpartum women.