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P1: CHOLINERGIC RECEPTOR FUNCTION IN CARDIAC ISCHEMIC PRECONDITIONING
Journal of Investigative Medicine
Purpose of Study Cardiac acetylcholine (ACh) signaling is protective, but the role of ACh in ischemic preconditioning (IPC) remains largely unknown. We studied the effect of selective alpha-7 nicotinic ACh receptor (a7nAChR) antagonism by methyllycaconitine (MLA) on the functional benefits of IPC and the effects of this on mitochondrial complexity and inner mitochondrial membrane potential (ψM). Methods Used Male Sprague Dawley rats (n=17, 322± 17 g) were heparinized and anesthetized with 80doi:10.1136/jim-2016-000080.41 fatcat:jhhvgjouefbgfnltnl6wiinijq