Various relations have been found out regarding the role of platelets in thrombosis and coronary heart disease. This study is an earnest attempt to delineate the relations between the various platelet volume indices (PVI) and their role in coronary heart disease. Method: During the study period of April 2014 to March 2015, total 180 subjects were studied. Out of them 120 were cases and 60 were controls. The cases of coronary artery disease were divided in to two groups A and B, according to

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... r treatment. Group A included 60 patients with acute coronary syndromes, mainly AMI and UA with medical treatment. Group B included 60 patients with any percutaneous coronary interventions (PCI) for previous ischemic event. Group C included 60 healthy individuals from health check-up unit. A brief and relevant clinical history and laboratory investigations will be taken on the prepared Performa for the subjects. The EDTA and plain samples of 180 subjects were processed in the Central Diagnostic Laboratory. Results: The present study showed higher PVI in the group A and group B when compared to the control group. MPV, PDW and P-LCR were signicantly reduced after treatment in both groups A and B. The mortality was more in those with higher PVI. Conclusion: Coronary artery disease is associated with signicant morbidity and mortality. Platelet volume indices in histograms are easily generated by automated cell counter. Thus, by assessment of it we can predict an impending coronary event. We can prevent reinfarction by monitoring of it. The risk of acute coronary event is also decreased after treatment.