Einfluss des Alters auf die Immunantwort und den Krankheitsverlauf bei schwerer Sepsis und septischem Schock - eine retrospektive Analyse der SBITS-Studie [article]

Maximilian Kurt Päsler, Bucher, M., Prof. Dr., Schreiber, J., Prof. Dr., Bauer, M., Prof. Dr., Martin-Luther Universität, Universitäts- Und Landesbibliothek Sachsen-Anhalt
2018
Function of the immune system undergoes severe changes during ageing, which might be one of the reasons for the increased risk of sepsis in older people. Methods: We analyzed inflammatory in different age groups on day 0 as well as their dynamics to day 4 in a analysis of the SBITS-trial. Additionally we examined the APACHE II Scores as a measurement for disease severity. Results: In older patients we saw a lower maximum body temperature on day 0 as well as higher serum sTNFRP 55 and 75 levels
more » ... P 55 and 75 levels on day 0. The dynamics to day 4 showed no differences between the age groups, although sTNFRP serum levels were still higher in older patients. Younger patients showed a faster recompensation. Pharmacokinetics of immunoglobulin G is equally effective in the old and young. Conclusions: We saw the initial hyperinflammation in older patients. The slower recovery of older patients might be caused by impaired physiological organ reserves as found in homoeostenosis. In summary we were able to prove the concept of immunosenescence in the context of severe sepsis and septic shock as older patients differed significantly from younger patients.
doi:10.25673/768 fatcat:zvwrxklqkbdddjxaza6tfiwefu