Sudden Sensorineural Hearing Loss after Granulocyte-Colony Stimulating Factor Administration

Seon-Lin Kim, 공수근, 고의경, Se-Joon Oh
2018 Journal of Clinical Otolaryngology  
Filgrastim Ⓡ (Granulocyte-colony stimulating factor, G-CSF) is generally used to promote the increase of neutrophils to patients with neutropenia during chemotherapy or donors for hematopoietic stem cell transplantation (HSCT). Its adverse effects were mainly reported as non-serious symptoms, such as back pain, headache, arthralgia and fever. A 29-year-old male was administered the Filgrastim as a HSCT donor. He accompanied left side hearing disturbance and tinnitus after 2 days from
more » ... ion of the drug. He admitted to our department and underwent improvement of hearing after high dose steroid therapy. In this report, we describe a case of sudden sensorineural hearing loss (SSNHL) as an unreported adverse effect of G-CSF in the literature.
doi:10.35420/jcohns.2018.29.1.87 fatcat:ng6ptpvwcfdfbha55zad4oj4xi