Synthesis of a proline-rich [60]fullerene peptide with potential biological activity

Panagiota Sofou, Yiannis Elemes, Eugenia Panou-Pomonis, Athanassios Stavrakoudis, Vassilios Tsikaris, Constantinos Sakarellos, Maria Sakarellos-Daitsiotis, Michele Maggini, Fernando Formaggio, Claudio Toniolo
<span title="">2004</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="" style="color: black;">Tetrahedron</a> </i> &nbsp;
A proline-rich [60]fullerene peptide was synthesized by use of (i) a 1,3-dipolar cycloaddition of an N-substituted glycine derivative to [60]fullerene, (ii) esterification of the isolated alcohol with the C-terminal amino acid of the desired peptide sequence, and finally (iii) coupling of the remaining hexapeptide to give the final product 8 as a TFA salt, with oxidized methionine. Product 8 was found to be biologically active against sera from MCTD and SLE patients (ELISA experiment). q
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="">doi:10.1016/j.tet.2004.01.064</a> <a target="_blank" rel="external noopener" href="">fatcat:5ydwmeougvc5piss3jrw2c5qhm</a> </span>
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