The Regional Innovation System (RIS) model provides important insights into the innovation performance of regions by investigating the interaction of organizations with each other and their environment in these regions. There is a lack of literature on RIS in resource-dependent rural and peripheral regions. This thesis contributes to our understanding of RIS in resource-based regions by investigating the interaction between the quadruple helix of government, post-secondary institutions, the

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... ate sector, and community organizations to investigate the current state of RIS in Corner Brook and its surrounding area in Newfoundland and Labrador (NL). To achieve this, this study uses context analysis and a case study approach. The thesis reveals a number of challenges and opportunities to further develop RIS in the region. The findings suggest that there is a lack of interaction among key quadruple helix actors of RIS in Corner Brook and its surrounding area, especially between the private sector and other actors of the quadruple helix. On the other hand, strong knowledge infrastructure, the presence of enough support organizations, rich natural resources, quality transportation infrastructure, and close-knit ties within the small community offer good prospects for the future of RIS in the region. Findings from the case study indicate that, although establishing cross-sectoral partnerships with the quadruple helix actors can be challenging and time-consuming, the application of this approach to develop innovation-based projects could offer tremendous benefits to the region. Based on the findings, recommendations are provided for each category of actors involved in the quadruple helix approach to encourage innovations in Corner Brook and the surrounding area.