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Olmesartan Medoxomil (OLM) is a selective AT1 subtype angiotensin-II receptor antagonist that is approved for the treatment of hypertension. It is having low aqueous solubility, so the present attempt is made to enhance the solubility of OLM by solid dispersion and complexation methods further formulating them into tablets by direct compression method. Solid dispersion and inclusion complex were prepared following solvent evaporation method using poloxamer 188 and β-cyclodextrin as afatcat:s7a4qmancrehxnqjvr2jlvlp4u