Journal of PharmaSciTech Formulation and Comparative Evaluation of Olmesartan Medoxomil Tablets by Solid Dispersion and Complexation Techniques

Amrit Timalsina, Mohammed Ahmed, Ankit Acharya
unpublished
Olmesartan Medoxomil (OLM) is a selective AT1 subtype angiotensin-II receptor antagonist that is approved for the treatment of hypertension. It is having low aqueous solubility, so the present attempt is made to enhance the solubility of OLM by solid dispersion and complexation methods further formulating them into tablets by direct compression method. Solid dispersion and inclusion complex were prepared following solvent evaporation method using poloxamer 188 and β-cyclodextrin as a
more » ... rin as a carrier.The prepared formulations were characterized for compatibility, drug content, saturation solubility and, dissolution studies. FT-IR study revealed no interaction between drug and excipients. Among all methods, solid dispersion (SD3) containing drug: poloxamer188 in the ratio of 1:3 showed rapid and higher drug release (85.36% within 45 min).The tablets prepared using SD3 solid dispersion and C3 inclusion complex were evaluated for both precompression and postcompression parameters. All the data obtained from the precompression and postcompression parameters fulfill the official requirements of tablets. The % drug release from the F1 batch tablet is higher (84.28%) than the F2 batch tablets (77.78%) within 45 minutes.Stability studies of F1 batch tablets showed no significant change in formulation during study period. Thus, it can be concluded that the formulation was stable.
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