Vit D Status and Osteoporosis in Tobacco Consuming Men in Rural Region Surrounding Wardha City, Maharashtra, Central Part of India
Indian Journal of Forensic Medicine & Toxicology
Awareness towards tobacco consumption has increased and it is well accepted too but will it help to cease the consumption. With widespread menace of tobacco consumption in developing country like India, not much data of study is available currently about tobacco consumption and osteoporosis around the rural region of Wardha a central part of India. Aim: Vit D status and osteoporosis in tobacco consumers and non consumers. Objective: To asses influence of tobacco consumption on Sr. Vit D, Sr.
... ized Ca, Sr. Phosphate, Sr. parathyroid hormones the biochemical markers of bone turnover and Bone mineral density in a cohort of 214 healthy men in rural area surrounding Wardha region of Maharashtra. Design: A cross sectional study Subjects: 214 healthy men aged around 30-50 years with no disease history were included in the study. Results: Tobacco consumers had significantly reduced levels of Sr 25 OH Vit D (P<0.02), PTH (P<0.001). There was no significant difference in Sr ionized Calcium between tobacco consumers and Non tobacco consumers. We got negative effect of tobacco consumption on Sr Osteocalcin (P<0.01). Conclusion: Calcium and Vit D metabolism is significantly deranged by habit of tobacco consumption and cannot be explained by life style factors. Vitamin D-PTH system depression among tobacco consumers represent a other mechanism for the deleterious effects of tobacco consumption on the bones and contribute to reported risk of osteoporosis among tobacco consumers. Sponsorship: Intra mural Grant from DMIMS(DU)