The Relationship Between Type 2 Diabetes Mellitus and Osteoporosis in Elderly People: a Cross-sectional Study

Mohammad Bayani, Ahmad Karkhah, Seyed Hoseini, Roya Qarouei, Haji Nourodini, Ali Bijani, Robert Cumming
2016 unpublished
Diabetes mellitus (DM) and osteoporosis are common diseases and their prevalence increases with age. Several investigations have indicated that type 1 DM has a significant relationship with bone loss, whereas in type 2 diabetes, this relationship is controversial. Therefore, this study was conducted to determine the relationship between osteoporosis and type 2 DM in elderly people. This population-based study had been carried out on 1151 elderly people in Amirkola, northern Iran. L2-L4 lumbar
more » ... ran. L2-L4 lumbar spine bone mass and the left femoral neck density were measured by dual-energy X-ray absorptiometry (DEXA). In addition, diagnosis of diabetes was done by measuring fasting blood sugar (twice times FBS ≥ 126 mg/dl), according to the WHO criteria or self-reported as well as based on a doctor's prescription. Of total, 362 (31.45%) of patients had DM. The average age of diabetic patients was 68.9± 6.93 years and in non-diabetic group was 68.68± 7.09 years (P= 0.18). The mean L2-L4 lumbar spine bone mass in the diabetic group was 0.90± 0.19 g/cm2 and in the non-diabetic group was 0.85± 0.18 g/cm2 (P= 0.001). The mean lumbar bone mineral density was higher (P= 0.0001) in diabetic men than in non-diabetic men, as well as in women (P= 0.0001). In addition, the mean femoral neck density in diabetic group was 0.85± 0.16 g/cm2 and in the non-diabetic group was 0.84± 0.15 g/cm2 (P= 0.48). Moreover, the femoral neck bone mineral density in diabetic men was higher than in non-diabetics (P= 0.03), whereas in diabetic and non-diabetic women, there was no significant difference (P= 0.52). Our results demonstrated that the mean lumbar and femur bone mineral densities in older people with type 2 DM was higher than people without DM.