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Maintenance of Peripheral Naive T Cells Is Sustained by Thymus Output in Mice but Not Humans
2012
Immunity
Parallels between T cell kinetics in mice and men have fueled the idea that a young mouse is a good model system for a young human, and an old mouse, for an elderly human. By combining in vivo kinetic labeling using deuterated water, thymectomy experiments, analysis of T cell receptor excision circles and CD31 expression, and mathematical modeling, we have quantified the contribution of thymus output and peripheral naive T cell division to the maintenance of T cells in mice and men. Aging
doi:10.1016/j.immuni.2012.02.006
pmid:22365666
fatcat:ph5snrk4ljfknbc2gz353n7i6q