Intestinal neoplasia in the ApcMin mouse: independence from the microbial and natural killer (beige locus) status

W F Dove, L Clipson, K A Gould, C Luongo, D J Marshall, A R Moser, M A Newton, R F Jacoby
1997 Cancer Research  
We have tested the hypothesis that enteric bacteria are necessary for formation of intestinal adenomas in C57BL/6-ApcMin/+ mouse. Germ-free mice developed 2-fold fewer adenomas than conventional controls in the medial small intestine (7.3 versus 14.9; P < 0.003), but there were no significant differences in the rest of the intestinal tract. We conclude that microbial status does not strongly alter the adenoma phenotype in this mouse model of familial adenomatous polyposis. In parallel, we have
more » ... ound that C57BL/6-ApcMin/+ mice mutated at the beige locus, which controls natural killer activity, are also unaltered in adenoma multiplicity.
pmid:9041176 fatcat:72ggupgwhjelrd5jma6ldcaa5i