ER -Specific Function Is Controlled by a Phosphotyrosine Switch

2014 Cancer Discovery  
September 2014 CANCER DISCOVERY | 985 rEsEarch Watch Major finding: TARBP2 binding to sRSEs within metastasis suppressor transcripts promotes their decay. Mechanism: TARBP2-driven breast cancer metastasis requires destabilization of the APP and ZNF395 transcripts. impact: Noncanonical pathways of post-transcriptional control can contribute to cancer progression. Yuan B, Cheng L, Chiang HC, Xu X, Han Y, Su H, et al. A phosphotyrosine switch determines the antitumor activity of ERβ.
doi:10.1158/ fatcat:tde3hub2ifclveszfs7ycptjsy