Discussion on the Biochemical Similarity in Metabolic Principles Based on Leucine Biosynthesis Pathway

Zhenxiong JIANG, 1 Department of Biology, Texas A&M University, College Station, TX 77840, USA,1 Department of Biology, Texas A & M University, College Station, TX 77840, USA, Peng WANG, Xinyu MA, Jie TIAN, Jun ZHANG, Hanjie JIANG, Jinhui SHI, Zhipeng A. WANG, 2 中山大学附属第一医院烧伤外科, 广州 510080,2 Department of Burn Surgery, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, P. R. China, 3 Department of Chemistry, Texas A&M University, College Station, TX 77840, USA,3 Department of Chemistry, Texas A & M University, College Station, TX 77840, USA, 4 Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA,4 Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Department of Biological Chemistry and Molecular, Pharmacology, Harvard Medical School, Boston, MA 02115, USA (+2 others)
2019 University Chemistry  
A deep insight into the diverse metabolic pathways gives us the possibility to find the similarities among those processes. This manuscript provides a new paradigm for chemical education using leucine metabolism as the example. Referring concepts from other disciplines, we generalized and summarized the chemical principles involved in the biological metabolisms. Further, patterns and causation behind the predominance of specific metabolic processes were explored through the comparison among
more » ... omparison among homologous enzymes in different pathways to ascertain their
doi:10.3866/pku.dxhx201808004 fatcat:deizd3rq5zbippdlpnbflwlg7e