17-Beta-Hydroxy-Steroid-Dehydrogenases in Hair Follicles of Normal and Bald Scalp: A Histochemical Study

Franco Crovato, Giuseppe Moretti, Rino Bertamino
1973 Journal of Investigative Dermatology  
Testosterone, dihydrotestosterone, and estradiol were used as substrates to evaluate 17 -beta-hydroxy-steroid-dehydrogenases in the ha ir follicles of normal hum a n scalp and scalps of patients affected by initial or advanced male pattern alopecia (MPA). Trace to strong re action s were found in follicles and moderate reactions were found in the dermal and hypodermal structures immediately surrounding the follicles. With testosterone and estradiol, the outer sheath of the late anagen follicles
more » ... in in.itial MPA showed greater reactivity than did s imilar follicles of norma l subjects. With dihydrotestosterone, reactivity in the outer sheath of normal late anagen follicles was strong and became progressively less strong in similar follicles from initial and advanced MPA subjects.
doi:10.1111/1523-1747.ep12682032 pmid:4699649 fatcat:icjxdzv7hnekjgkai3fpkvuzoi