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Testosterone, dihydrotestosterone, and estradiol were used as substrates to evaluate 17 -beta-hydroxy-steroid-dehydrogenases in the ha ir follicles of normal hum a n scalp and scalps of patients affected by initial or advanced male pattern alopecia (MPA). Trace to strong re action s were found in follicles and moderate reactions were found in the dermal and hypodermal structures immediately surrounding the follicles. With testosterone and estradiol, the outer sheath of the late anagen folliclesdoi:10.1111/1523-1747.ep12682032 pmid:4699649 fatcat:icjxdzv7hnekjgkai3fpkvuzoi