Malignant melanoma (MM) represents 1% of all cancers and has an incidence of 3% -7% in the female genital tract, the majority of cases being reported in the vulva. The cervico-vaginal region is an unusual primary location of the malignant melanoma. Case report: The clinical and morphologic findings of 3 MM patients with cervico-vaginal tumours mimicking cervical polyp in third case. Histologically, the neoplasia was formed by nodules of broad cytoplasmic cells with poorly defined borders with

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... eomorphic nuclei with prominent nucleolar. Tumor cells were positive for S-100 protein, Melan A, HMB 45 and CD117. The authors discuss three cases of cervico-vaginal melanoma and analyze clinical and prognostic aspects of this disease. Conclusion: Primary MM of the cervix should be considered in the differential diagnosis of cervical malignancies. Early diagnosis is essential in order to warrant a better prognosis, although there are no cases of cure described.