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Amyloid Fibrils of Mammalian Prion Protein Are Highly Toxic to Cultured Cells and Primary Neurons
2006
Journal of Biological Chemistry
A growing body of evidence indicates that small, soluble oligomeric species generated from a variety of proteins and peptides rather than mature amyloid fibrils are inherently highly cytotoxic. Here, we show for the first time that mature amyloid fibrils produced from full-length recombinant mammalian prion protein (rPrP) were highly toxic to cultured cells and primary hippocampal and cerebella neurons. Fibrils induced apoptotic cell death in a time-and dose-dependent manner. The toxic effect
doi:10.1074/jbc.m511174200
pmid:16554307
fatcat:tvmlzndrfvhr5bemrwbsshnfum