Marine Spirotetronates: Biosynthetic Edifices That Inspire Drug Discovery

Alexander A. Braddock, Emmanuel A. Theodorakis
2019 Marine Drugs  
Spirotetronates are actinomyces-derived polyketides that possess complex structures and exhibit potent and unexplored bioactivities. Due to their anticancer and antimicrobial properties, they have potential as drug hits and deserve further study. In particular, abyssomicin C and tetrocarcin A have shown significant promise against antibiotic-resistant S. aureus and tuberculosis, as well as for the treatment of various lymphomas and solid tumors. Improved synthetic routes to these compounds,
more » ... icularly the class II spirotetronates, are needed to access sufficient quantities for structure optimization and clinical applications.
doi:10.3390/md17040232 fatcat:bmoryjqwf5djpdyedyxueyezki