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The transfer matrix method is used to simulate the magneto-optic surface plasmon resonance (MOSPR) of Au/Co/Au trilayer systems focused on the magneto-optic activity in transverse configuration. The results show a strong thickness dependence of the normalized difference of reflectivity at opposite directions of the magnetization (d-signal) and a strong change of the d-signal with the refractive index n of the biologically active layer. Within a range of the refractive index typically covered bydoi:10.1063/1.4742130 fatcat:vmv4glwjx5dlpjeba7jjijgsxe