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The eXtensible ontology development (XOD) strategy proposes four principles to support interoperable and robust ontology development. These principles include ontology term reuse, semantic alignment, design pattern usage, and community extensibility. In this software demo, we show how Ontoanimal tools (e.g., Ontofox, Ontodog, Ontorat, and Ontokiwi) can be used to support the implementation of these XOD principles. The development of the Cell Line Ontology (CLO) is used for the demonstration.dblp:conf/icbo/OngH018 fatcat:cptx7yrcezcm5hijfjhimlkj24